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Gene: BRSK2 (BR serine/threonine kinase 2) Homo sapiens
Symbol: BRSK2
Name: BR serine/threonine kinase 2
Description: Exhibits several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including cellular protein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Localizes to centrosome and endoplasmic reticulum; INTERACTS WITH aflatoxin B1; aflatoxin B2; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BR serine/threonine-protein kinase 2; brain-selective kinase 2; brain-specific serine/threonine-protein kinase 2; C11orf7; FLJ41362; PEN11B; protein kinase SAD1B; SAD1; SADA; serine/threonine kinase 29; serine/threonine kinase SAD-A; serine/threonine-protein kinase 29; serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase SAD-A; STK29; testicular tissue protein Li 30
Mus musculus (house mouse) : Brsk2 (BR serine/threonine kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Brsk2 (BR serine/threonine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brsk2 (BR serine/threonine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BRSK2 (BR serine/threonine kinase 2)
Canis lupus familiaris (dog) : BRSK2 (BR serine/threonine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brsk2 (BR serine/threonine kinase 2)
Sus scrofa (pig) : BRSK2 (BR serine/threonine kinase 2)
Chlorocebus sabaeus (African green monkey) : BRSK2 (BR serine/threonine kinase 2)
Heterocephalus glaber (naked mole-rat) : Brsk2 (BR serine/threonine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,389,899 - 1,462,689 (+)EnsemblGRCh38hg38GRCh38
GRCh38111,389,934 - 1,462,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,411,129 - 1,483,919 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,367,705 - 1,439,908 (+)NCBINCBI36hg18NCBI36
Build 34111,367,704 - 1,439,902NCBI
Celera111,444,570 - 1,515,142 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,221,716 - 1,271,938 (+)NCBIHuRef
CHM1_1111,410,344 - 1,482,831 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on BRSK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345228
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.