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Gene: GRN (granulin precursor) Homo sapiens
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Symbol: GRN
Name: granulin precursor
Description: Exhibits chaperone binding activity. Involved in several processes, including lysosomal lumen acidification; negative regulation of respiratory burst involved in inflammatory response; and positive regulation of lysosome organization. Localizes to several cellular components, including the Golgi apparatus; late endosome; and lysosomal membrane. Implicated in dementia (multiple); neurodegenerative disease (multiple); and neuronal ceroid lipofuscinosis 11. Biomarker of Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; atherosclerosis; autistic disorder; bipolar disorder; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acrogranin; CLN11; epithelin; GEP; glycoprotein 88; glycoprotein of 88 Kda; GP88; granulin; granulin-epithelin; granulins; PC cell-derived growth factor; PCDGF; PEPI; PGRN; proepithelin; progranulin
Orthologs:
Mus musculus (house mouse) : Grn (granulin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grn (granulin precursor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grn (granulin precursor)
Pan paniscus (bonobo/pygmy chimpanzee) : GRN (granulin precursor)
Canis lupus familiaris (dog) : GRN (granulin precursor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grn (granulin precursor)
Sus scrofa (pig) : GRN (granulin precursor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,345,086 - 44,353,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371742,422,491 - 42,430,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,778,017 - 39,785,996 (+)NCBINCBI36hg18NCBI36
Build 341739,778,016 - 39,785,996NCBI
Celera1739,132,112 - 39,140,095 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1738,186,768 - 38,194,753 (+)NCBIHuRef
CHM1_11742,658,129 - 42,666,150 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GRN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345254
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.