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Gene: AKAP5 (A-kinase anchoring protein 5) Homo sapiens
Symbol: AKAP5
Name: A-kinase anchoring protein 5
Description: Exhibits several functions, including SH3 domain binding activity; enzyme binding activity; and protein kinase A regulatory subunit binding activity. Involved in several processes, including negative regulation of adenylate cyclase activity; positive regulation of protein localization to plasma membrane; and regulation of protein kinase A signaling. Localizes to the cytoplasmic side of plasma membrane and membrane raft. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; AKAP 79; AKAP-5; AKAP75; AKAP79; cAMP-dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21
Mus musculus (house mouse) : Akap5 (A kinase (PRKA) anchor protein 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akap5 (A-kinase anchoring protein 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akap5 (A-kinase anchoring protein 5)
Pan paniscus (bonobo/pygmy chimpanzee) : AKAP5 (A-kinase anchoring protein 5)
Canis lupus familiaris (dog) : AKAP5 (A-kinase anchoring protein 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akap5 (A-kinase anchoring protein 5)
Sus scrofa (pig) : AKAP5 (A-kinase anchoring protein 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381464,465,499 - 64,474,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371464,932,217 - 64,941,221 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,001,970 - 64,010,974 (+)NCBINCBI36hg18NCBI36
Build 341464,003,577 - 64,006,172NCBI
Celera1444,989,946 - 44,998,950 (+)NCBI
Cytogenetic Map14q23.3ENTREZGENE
HuRef1445,104,846 - 45,113,850 (+)NCBIHuRef
CHM1_11464,871,930 - 64,880,934 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKAP5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345297
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.