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Gene: ITGB3 (integrin subunit beta 3) Homo sapiens
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Symbol: ITGB3
Name: integrin subunit beta 3
CRRD ID: 1345363
Description: Exhibits several functions, including fibronectin binding activity; protein disulfide isomerase activity; and signaling receptor binding activity. Contributes to C-X3-C chemokine binding activity and growth factor binding activity. Involved in several processes, including negative regulation of lipid localization; negative regulation of macrophage derived foam cell differentiation; and regulation of protein metabolic process. Localizes to several cellular components, including alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and cell projection membrane. Implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Biomarker of several diseases, including Graves' disease; carcinoma (multiple); diabetic retinopathy; myelodysplastic syndrome; and platelet-type bleeding disorder 16.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen CD61; BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; integrin beta 3; integrin beta chain, beta 3; integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa
Orthologs:
Mus musculus (house mouse) : Itgb3 (integrin beta 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgb3 (integrin subunit beta 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb3 (integrin subunit beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB3 (integrin subunit beta 3)
Canis lupus familiaris (dog) : ITGB3 (integrin subunit beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb3 (integrin subunit beta 3)
Sus scrofa (pig) : ITGB3 (integrin subunit beta 3)
Chlorocebus sabaeus (African green monkey) : ITGB3 (integrin subunit beta 3)
Heterocephalus glaber (naked mole-rat) : Itgb3 (integrin subunit beta 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1747,253,846 - 47,311,816 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1747,253,846 - 47,313,735 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1747,253,827 - 47,313,743 (+)EnsemblGRCh38hg38GRCh38
GRCh381747,253,827 - 47,313,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371745,331,208 - 45,390,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,686,207 - 42,745,076 (+)NCBINCBI36hg18NCBI36
Build 341742,686,206 - 42,745,076NCBI
Celera1741,781,276 - 41,840,192 (+)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1740,709,287 - 40,768,167 (+)NCBIHuRef
CHM1_11745,396,156 - 45,455,032 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ITGB3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345363
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.