Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DUSP9 (dual specificity phosphatase 9) Homo sapiens
Analyze
Symbol: DUSP9
Name: dual specificity phosphatase 9
Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity protein phosphatase 9; map kinase phosphatase 4; mitogen-activated protein kinase phosphatase 4; MKP-4; MKP4; serine/threonine specific protein phosphatase
Orthologs:
Mus musculus (house mouse) : Dusp9 (dual specificity phosphatase 9)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dusp9 (dual specificity phosphatase 9)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp9 (dual specificity phosphatase 9)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP9 (dual specificity phosphatase 9)
Canis lupus familiaris (dog) : DUSP9 (dual specificity phosphatase 9)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp9 (dual specificity phosphatase 9)
Sus scrofa (pig) : DUSP9 (dual specificity phosphatase 9)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,642,443 - 153,651,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X152,907,897 - 152,916,781 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,561,182 - 152,569,971 (+)NCBINCBI36hg18NCBI36
Build 34X152,428,834 - 152,437,623NCBI
CeleraX153,141,581 - 153,150,465 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,570,975 - 141,574,303 (+)NCBIHuRef
CHM1_1X152,782,380 - 152,791,259 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DUSP9
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345424
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.