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Gene: GRK1 (G protein-coupled receptor kinase 1) Homo sapiens
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Symbol: GRK1
Name: G protein-coupled receptor kinase 1
Description: Exhibits rhodopsin kinase activity. Involved in protein autophosphorylation and regulation of rhodopsin mediated signaling pathway. Predicted to localize to the photoreceptor disc membrane. Implicated in Oguchi disease-2 and night blindness.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GPRK1; rhodopsin kinase; rhodopsin kinase GRK1; RHOK; RK
Orthologs:
Mus musculus (house mouse) : Grk1 (G protein-coupled receptor kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grk1 (G protein-coupled receptor kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk1 (G protein-coupled receptor kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK1 (G protein-coupled receptor kinase 1)
Canis lupus familiaris (dog) : GRK1 (G protein-coupled receptor kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk1 (G protein-coupled receptor kinase 1)
Sus scrofa (pig) : GRK1 (G protein-coupled receptor kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_027140.7 and the 3' end was annotated on NT_024498.13 in NCBI s Homo sapiens Annotation Release 106. [17 Jun 2014]; Annotation category: suggests misassembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,645,771 - 113,737,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713114,426,046 - 114,438,637 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3713114,321,594 - 114,325,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,369,595 - 113,373,975 (+)NCBINCBI36hg18NCBI36
Build 3413113,369,597 - 113,373,973NCBI
Celera1395,148,890 - 95,166,521 (+)NCBI
Cytogenetic Map13q34NCBI
HuRef1394,760,843 - 94,763,381 (+)NCBIHuRef
HuRef1394,993,393 - 94,997,833 (-)NCBIHuRef
CHM1_113114,290,923 - 114,407,284 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GRK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345543
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.