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Gene: GRK1 (G protein-coupled receptor kinase 1) Homo sapiens
Symbol: GRK1
Name: G protein-coupled receptor kinase 1
Description: Exhibits rhodopsin kinase activity. Involved in protein autophosphorylation and regulation of rhodopsin mediated signaling pathway. Predicted to localize to the photoreceptor disc membrane. Implicated in Oguchi disease-2 and night blindness.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GPRK1; rhodopsin kinase; rhodopsin kinase GRK1; RHOK; RK
Mus musculus (house mouse) : Grk1 (G protein-coupled receptor kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grk1 (G protein-coupled receptor kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk1 (G protein-coupled receptor kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK1 (G protein-coupled receptor kinase 1)
Canis lupus familiaris (dog) : GRK1 (G protein-coupled receptor kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk1 (G protein-coupled receptor kinase 1)
Sus scrofa (pig) : GRK1 (G protein-coupled receptor kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_027140.7 and the 3' end was annotated on NT_024498.13 in NCBI s Homo sapiens Annotation Release 106. [17 Jun 2014]; Annotation category: suggests misassembly
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3813113,645,771 - 113,737,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713114,426,046 - 114,438,637 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3713114,321,594 - 114,325,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,369,595 - 113,373,975 (+)NCBINCBI36hg18NCBI36
Build 3413113,369,597 - 113,373,973NCBI
Celera1395,148,890 - 95,166,521 (+)NCBI
Cytogenetic Map13q34NCBI
HuRef1394,760,843 - 94,763,381 (+)NCBIHuRef
HuRef1394,993,393 - 94,997,833 (-)NCBIHuRef
CHM1_113114,290,923 - 114,407,284 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GRK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345543
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.