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Gene: GLIS2 (GLIS family zinc finger 2) Homo sapiens
Symbol: GLIS2
Name: GLIS family zinc finger 2
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Predicted to localize to the nuclear speck. Implicated in nephronophthisis 7.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ38247; GLI-similar 2; GLI-similar protein 2; Kruppel-like zinc finger protein GLIS2; nephrocystin-7; neuronal Krueppel-like protein; NKL; NPHP7; zinc finger protein GLIS2
Mus musculus (house mouse) : Glis2 (GLIS family zinc finger 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Glis2 (GLIS family zinc finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glis2 (GLIS family zinc finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GLIS2 (GLIS family zinc finger 2)
Canis lupus familiaris (dog) : GLIS2 (GLIS family zinc finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glis2 (GLIS family zinc finger 2)
Sus scrofa (pig) : GLIS2 (GLIS family zinc finger 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38164,314,761 - 4,339,597 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37164,366,240 - 4,389,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,322,226 - 4,329,599 (+)NCBINCBI36hg18NCBI36
Build 34164,322,225 - 4,327,803NCBI
Celera164,589,173 - 4,596,546 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef164,349,132 - 4,356,464 (+)NCBIHuRef
CHM1_1164,364,701 - 4,389,534 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GLIS2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345602
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.