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Gene: EPHA4 (EPH receptor A4) Homo sapiens
Symbol: EPHA4
Name: EPH receptor A4
CRRD ID: 1345605
Description: Exhibits protein domain specific binding activity; protein kinase activity; and protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of Rho guanyl-nucleotide exchange factor activity; positive regulation of amyloid precursor protein catabolic process; and protein phosphorylation. Predicted to localize to several cellular components, including dendrite; early endosome membrane; and integral component of postsynaptic membrane. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EK8; EPH-like kinase 8; ephrin type-A receptor 4; HEK8; receptor protein-tyrosine kinase HEK8; SEK; TYRO1; TYRO1 protein tyrosine kinase; tyrosine-protein kinase receptor SEK; tyrosine-protein kinase TYRO1
Mus musculus (house mouse) : Epha4 (Eph receptor A4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Epha4 (Eph receptor A4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epha4 (EPH receptor A4)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHA4 (EPH receptor A4)
Canis lupus familiaris (dog) : EPHA4 (EPH receptor A4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epha4 (EPH receptor A4)
Sus scrofa (pig) : EPHA4 (EPH receptor A4)
Chlorocebus sabaeus (African green monkey) : EPHA4 (EPH receptor A4)
Heterocephalus glaber (naked mole-rat) : Epha4 (EPH receptor A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2221,418,027 - 221,574,202 (-)EnsemblGRCh38hg38GRCh38
GRCh382221,418,027 - 221,574,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,282,747 - 222,437,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,990,991 - 222,145,254 (-)NCBINCBI36hg18NCBI36
Build 342222,108,253 - 222,262,515NCBI
Celera2216,050,899 - 216,205,191 (-)NCBI
Cytogenetic Map2q36.1NCBI
HuRef2214,137,116 - 214,291,409 (-)NCBIHuRef
CHM1_12222,288,287 - 222,444,796 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EPHA4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345605
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.