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Gene: EPHA4 (EPH receptor A4) Homo sapiens
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Symbol: EPHA4
Name: EPH receptor A4
Description: Exhibits protein domain specific binding activity; protein kinase activity; and protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of Rho guanyl-nucleotide exchange factor activity; positive regulation of amyloid precursor protein catabolic process; and protein phosphorylation. Predicted to localize to several cellular components, including the axon; dendrite; and early endosome membrane. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EK8; EPH-like kinase 8; ephrin type-A receptor 4; HEK8; receptor protein-tyrosine kinase HEK8; SEK; TYRO1; TYRO1 protein tyrosine kinase; tyrosine-protein kinase receptor SEK; tyrosine-protein kinase TYRO1
Orthologs:
Mus musculus (house mouse) : Epha4 (Eph receptor A4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Epha4 (Eph receptor A4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epha4 (EPH receptor A4)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHA4 (EPH receptor A4)
Canis lupus familiaris (dog) : EPHA4 (EPH receptor A4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epha4 (EPH receptor A4)
Sus scrofa (pig) : EPHA4 (EPH receptor A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,418,027 - 221,574,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,282,747 - 222,437,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,990,991 - 222,145,254 (-)NCBINCBI36hg18NCBI36
Build 342222,108,253 - 222,262,515NCBI
Celera2216,050,899 - 216,205,191 (-)NCBI
Cytogenetic Map2q36.1NCBI
HuRef2214,137,116 - 214,291,409 (-)NCBIHuRef
CHM1_12222,288,287 - 222,444,796 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EPHA4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345605
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.