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Gene: CCR3 (C-C motif chemokine receptor 3) Homo sapiens
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Symbol: CCR3
Name: C-C motif chemokine receptor 3
Description: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: b-chemokine receptor; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CC-CKR-3; CCR-3; CD193; chemokine (C-C motif) receptor 3; CKR3; CMKBR3; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor; MGC102841
Orthologs:
Mus musculus (house mouse) : Ccr3 (chemokine (C-C motif) receptor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccr3 (C-C motif chemokine receptor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccr3 (C-C motif chemokine receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CCR3 (C-C motif chemokine receptor 3)
Canis lupus familiaris (dog) : CCR3 (C-C motif chemokine receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccr3 (C-C motif chemokine receptor 3)
Sus scrofa (pig) : CCR3 (C-C motif chemokine receptor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,210,699 - 46,266,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,283,872 - 46,308,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,258,692 - 46,283,166 (+)NCBINCBI36hg18NCBI36
Build 34346,258,691 - 46,283,166NCBI
Celera346,221,217 - 46,245,543 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,327,575 - 46,351,905 (+)NCBIHuRef
CHM1_1346,233,878 - 46,258,185 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CCR3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345616
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.