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Gene: HCFC1 (host cell factor C1) Homo sapiens
Symbol: HCFC1
Name: host cell factor C1
Description: This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C1 factor; CFF; HCF; HCF-1; HCF1; HFC1; host cell factor 1; mental retardation, X-linked 3; MGC70925; MRX3; PPP1R89; VCAF; VP16 accessory protein
Mus musculus (house mouse) : Hcfc1 (host cell factor C1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hcfc1 (host cell factor C1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hcfc1 (host cell factor C1)
Pan paniscus (bonobo/pygmy chimpanzee) : HCFC1 (host cell factor C1)
Canis lupus familiaris (dog) : HCFC1 (host cell factor C1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hcfc1 (host cell factor C1)
Sus scrofa (pig) : HCFC1 (host cell factor C1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X153,947,556 - 153,972,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,213,008 - 153,237,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,866,202 - 152,890,013 (-)NCBINCBI36hg18NCBI36
Build 34X152,733,854 - 152,751,024NCBI
CeleraX153,446,719 - 153,470,530 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,865,579 - 141,889,655 (-)NCBIHuRef
CHM1_1X153,087,420 - 153,111,232 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HCFC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345622
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.