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Gene: SMS (spermine synthase) Homo sapiens
Symbol: SMS
Name: spermine synthase
Description: This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MRSR; Snyder-Robinson X-linked mental retardation syndrome; spermidine aminopropyltransferase; SPMSY; SpS; SRS
Mus musculus (house mouse) : Sms (spermine synthase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sms (spermine synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sms (spermine synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : SMS (spermine synthase)
Canis lupus familiaris (dog) : SMS (spermine synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sms (spermine synthase)
Sus scrofa (pig) : SMS (spermine synthase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X21,940,573 - 21,994,837 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X21,958,691 - 22,025,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,868,763 - 21,922,876 (+)NCBINCBI36hg18NCBI36
Build 34X21,718,498 - 21,772,611NCBI
CeleraX26,079,796 - 26,133,909 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX19,699,279 - 19,753,795 (+)NCBIHuRef
CHM1_1X21,989,118 - 22,043,385 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SMS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345734
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.