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Gene: SMURF2 (SMAD specific E3 ubiquitin protein ligase 2) Homo sapiens
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Symbol: SMURF2
Name: SMAD specific E3 ubiquitin protein ligase 2
Description: Exhibits SMAD binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent SMAD protein catabolic process. Localizes to nuclear speck and ubiquitin ligase complex; PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH 1-nitropyrene; 17beta-estradiol; 2-hydroxypropanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp686F0270; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; MGC138150; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
Orthologs:
Mus musculus (house mouse) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
Canis lupus familiaris (dog) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)
Sus scrofa (pig) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
Chlorocebus sabaeus (African green monkey) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
Heterocephalus glaber (naked mole-rat) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)
more info ...
Related Pseudogenes: SMURF2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1764,542,282 - 64,662,307 (-)EnsemblGRCh38hg38GRCh38
GRCh381764,542,282 - 64,662,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371762,538,400 - 62,658,386 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,971,197 - 60,088,848 (-)NCBINCBI36hg18NCBI36
Build 341759,971,196 - 60,088,848NCBI
Celera1757,011,021 - 57,128,748 (-)NCBI
Cytogenetic Map17q23.3-q24.1NCBI
HuRef1757,990,112 - 58,108,347 (-)NCBIHuRef
CHM1_11762,604,658 - 62,722,343 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

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Additional Information

External Database Links
 
More on SMURF2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345810
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.