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Gene: ASPN (asporin) Homo sapiens
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Symbol: ASPN
Name: asporin
Description: Exhibits calcium ion binding activity. Involved in bone mineralization and negative regulation of transforming growth factor beta receptor signaling pathway. Localizes to the extracellular matrix. Implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Biomarker of degenerative disc disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: asporin (LRR class 1); asporin proteoglycan; FLJ20129; OS3; periodontal ligament associated protein 1; periodontal ligament-associated protein 1; PLAP-1; PLAP1; SLRR1C; small leucine-rich protein 1C
Orthologs:
Mus musculus (house mouse) : Aspn (asporin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aspn (asporin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aspn (asporin)
Pan paniscus (bonobo/pygmy chimpanzee) : ASPN (asporin)
Canis lupus familiaris (dog) : ASPN (asporin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aspn (asporin)
Sus scrofa (pig) : ASPN (asporin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38992,456,205 - 92,482,506 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37995,218,487 - 95,244,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,258,308 - 94,284,609 (-)NCBINCBI36hg18NCBI36
Build 34992,298,045 - 92,324,343NCBI
Celera965,660,507 - 65,686,862 (-)NCBI
Cytogenetic Map9q22.31NCBI
HuRef964,895,929 - 64,922,284 (-)NCBIHuRef
CHM1_1995,364,907 - 95,391,264 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ASPN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345823
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.