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Gene: EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) Homo sapiens
Symbol: EIF2AK2
Name: eukaryotic translation initiation factor 2 alpha kinase 2
CRRD ID: 1345835
Description: Exhibits double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of NF-kappaB transcription factor activity; and regulation of cellular protein metabolic process. Localizes to cytosol and perinuclear region of cytoplasm. Implicated in Alzheimer's disease; Huntington's disease; and Parkinson's disease. Biomarker of amyotrophic lateral sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: double stranded RNA activated protein kinase; eIF-2A protein kinase 2; EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; interferon-inducible RNA-dependent protein kinase; LEUDEN; MGC126524; P1/eIF-2A protein kinase; p68 kinase; PKR; PPP1R83; PRKR; protein kinase RNA-activated; protein kinase, interferon-inducible double stranded RNA dependent; tyrosine-protein kinase EIF2AK2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl237,099,210 - 37,157,065 (-)EnsemblGRCh38hg38GRCh38
GRCh38237,099,210 - 37,157,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37237,332,281 - 37,384,190 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,187,203 - 37,237,572 (-)NCBINCBI36hg18NCBI36
Build 34237,245,349 - 37,295,719NCBI
Celera237,174,728 - 37,225,214 (-)NCBI
Cytogenetic Map2p22.2NCBI
HuRef237,072,482 - 37,124,338 (-)NCBIHuRef
CHM1_1237,261,631 - 37,313,513 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EIF2AK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345835
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.