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Gene: MAP3K15 (mitogen-activated protein kinase kinase kinase 15) Homo sapiens
Symbol: MAP3K15
Name: mitogen-activated protein kinase kinase kinase 15
Description: The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis signal-regulating kinase 3; ASK3; bA723P2.3; FLJ16518; MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X19,360,058 - 19,515,261 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X19,378,174 - 19,533,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X19,288,095 - 19,410,315 (-)NCBINCBI36hg18NCBI36
Build 34X19,137,830 - 19,260,051NCBI
CeleraX23,499,514 - 23,656,927 (-)NCBI
Cytogenetic MapXp22.12NCBI
HuRefX17,127,352 - 17,281,966 (-)NCBIHuRef
CHM1_1X19,409,233 - 19,563,759 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAP3K15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345894
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.