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Gene: KLF5 (Kruppel like factor 5) Homo sapiens
Symbol: KLF5
Name: Kruppel like factor 5
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in cell-cell signaling via exosome and positive regulation of pri-miRNA transcription by RNA polymerase II. Localizes to the Golgi apparatus and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: (intestinal Kruppel-like factor; basic transcription element binding protein 2; basic transcription element-binding protein 2; BTE-binding protein 2; BTEB2; CKLF; colon krueppel-like factor; colon kruppel-like factor; GC box binding protein 2; GC-box-binding protein 2; IKLF; intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; Klf5C isoform; Krueppel-like factor 5; Kruppel-like factor 5 (intestinal); transcription factor BTEB2
Mus musculus (house mouse) : Klf5 (Kruppel-like factor 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Klf5 (Kruppel-like factor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf5 (Kruppel like factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF5 (Kruppel like factor 5)
Canis lupus familiaris (dog) : KLF5 (Kruppel like factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf5 (Kruppel like factor 5)
Sus scrofa (pig) : KLF5 (Kruppel like factor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381373,054,976 - 73,077,542 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371373,629,114 - 73,651,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,531,143 - 72,549,677 (+)NCBINCBI36hg18NCBI36
Build 341372,531,142 - 72,549,677NCBI
Celera1354,531,627 - 54,550,162 (+)NCBI
Cytogenetic Map13q22.1NCBI
HuRef1354,330,388 - 54,348,922 (+)NCBIHuRef
CHM1_11373,596,724 - 73,619,293 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KLF5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345927
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.