Gene: KLF5 (Kruppel like factor 5) Homo sapiens
Analyze
Symbol:
KLF5
Name:
Kruppel like factor 5
Description:
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in cell-cell signaling via exosome and positive regulation of pri-miRNA transcription by RNA polymerase II. Localizes to the Golgi apparatus and nucleoplasm.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
(intestinal Kruppel-like factor; basic transcription element binding protein 2; basic transcription element-binding protein 2; BTE-binding protein 2; BTEB2; CKLF; colon krueppel-like factor; colon kruppel-like factor; GC box binding protein 2; GC-box-binding protein 2; IKLF; intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; Klf5C isoform; Krueppel-like factor 5; Kruppel-like factor 5 (intestinal); transcription factor BTEB2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Klf5 (Kruppel-like factor 5) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Klf5 (Kruppel-like factor 5) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Klf5 (Kruppel like factor 5) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
KLF5 (Kruppel like factor 5) NCBI
Ortholog
Canis lupus familiaris (dog):
KLF5 (Kruppel like factor 5) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Klf5 (Kruppel like factor 5) NCBI
Ortholog
Sus scrofa (pig):
KLF5 (Kruppel like factor 5) HGNC
Ensembl, NCBI, OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Klf5 (Kruppel-like factor 5)
Alliance
DIOPT (Ensembl Compara, HGNC, OMA, OrthoFinder, PANTHER, TreeFam)
Mus musculus (house mouse):
Klf5 (Kruppel-like factor 5)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
klf5a (Kruppel-like factor 5a)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, TreeFam, ZFIN)
Danio rerio (zebrafish):
klf5b (Kruppel-like factor 5b)
Alliance
DIOPT (Ensembl Compara, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
klf5l (Kruppel-like factor 5 like)
Alliance
DIOPT (Hieranoid, OrthoFinder, PANTHER)
Caenorhabditis elegans (roundworm):
klf-2
Alliance
DIOPT (Hieranoid, TreeFam)
Drosophila melanogaster (fruit fly):
dar1
Alliance
DIOPT (Ensembl Compara, OrthoInspector, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 13 73,054,976 - 73,077,542 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 13 73,629,114 - 73,651,676 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 13 72,531,143 - 72,549,677 (+) NCBI NCBI36 hg18 NCBI36 Build 34 13 72,531,142 - 72,549,677 NCBI Celera 13 54,531,627 - 54,550,162 (+) NCBI Cytogenetic Map 13 q22.1 NCBI HuRef 13 54,330,388 - 54,348,922 (+) NCBI HuRef CHM1_1 13 73,596,724 - 73,619,293 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Chromosome 13q Deletion Syndrome IAGP RGD:13828542 8554872 ClinVar Annotator: match by term: CHROMOSOME 13q DELETION SYNDROME ClinVar chromosome 13q14 deletion syndrome IAGP RGD:13828542 8554872 ClinVar Annotator: match by term: Chromosome 13q14 deletion syndrome ClinVar
Imported Annotations - CTD
chronic obstructive pulmonary disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30639269 Colorectal Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30510241 Neointima EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16224062 pancreatic cancer EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26098869 squamous cell carcinoma EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27158780 urinary bladder cancer EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27514407
(+)-catechin multiple interactions EXP 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of KLF5 mRNA CTD PMID:24763279 (+)-schisandrin B multiple interactions ISO RGD:621446 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of KLF5 mRNA] CTD PMID:31150632 (2,4,5-trichlorophenoxy)acetic acid increases expression ISO RGD:1551083 6480464 2 more ... CTD PMID:18579281 1,2,4-trimethylbenzene decreases expression ISO RGD:621446 6480464 pseudocumene results in decreased expression of KLF5 protein CTD PMID:17337753 17alpha-ethynylestradiol increases expression ISO RGD:1551083 6480464 Ethinyl Estradiol results in increased expression of KLF5 mRNA CTD PMID:17942748 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of KLF5 mRNA CTD PMID:19167446 17beta-estradiol multiple interactions ISO RGD:621446 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of KLF5 mRNA CTD PMID:26496021 17beta-hydroxy-5alpha-androstan-3-one increases expression EXP 6480464 Dihydrotestosterone results in increased expression of KLF5 mRNA CTD PMID:29581250 2,2',5,5'-tetrachlorobiphenyl decreases expression ISO RGD:621446 6480464 2 more ... CTD PMID:23829299 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1551083 6480464 Tetrachlorodibenzodioxin results in increased expression of KLF5 mRNA CTD PMID:18691609 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of KLF5 mRNA CTD PMID:12377990 , PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551083 6480464 Tetrachlorodibenzodioxin affects the expression of KLF5 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:621446 6480464 Tetrachlorodibenzodioxin results in increased expression of KLF5 mRNA CTD PMID:20558275 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of KLF5 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1551083 6480464 Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF5 mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KLF5 promoter] CTD PMID:16054899 , PMID:19654925 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1551083 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA more ... CTD PMID:16054899 more ... 3-methylcholanthrene increases expression ISO RGD:1551083 6480464 Methylcholanthrene results in increased expression of KLF5 mRNA CTD PMID:20713471 4-hydroxyphenyl retinamide increases expression ISO RGD:1551083 6480464 Fenretinide results in increased expression of KLF5 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [Decitabine co-treated with trichostatin A] results in increased expression of KLF5 mRNA CTD PMID:20678512 5-fluorouracil multiple interactions EXP 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of KLF5 mRNA] CTD PMID:15016801 6-propyl-2-thiouracil affects expression ISO RGD:621446 6480464 Propylthiouracil affects the expression of KLF5 mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:621446 6480464 Acrylamide results in decreased expression of KLF5 mRNA CTD PMID:28959563 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of KLF5 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:621446 6480464 Aflatoxin B1 results in increased expression of KLF5 mRNA CTD PMID:23630614 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of KLF5 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of KLF5 mRNA CTD PMID:21934132 all-trans-retinoic acid multiple interactions ISO RGD:1551083 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of KLF5 mRNA CTD PMID:30951980 ammonium chloride affects expression ISO RGD:621446 6480464 Ammonium Chloride affects the expression of KLF5 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1551083 6480464 pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA] CTD PMID:17460151 arachidonic acid increases expression EXP 6480464 Arachidonic Acid results in increased expression of KLF5 mRNA CTD PMID:16704987 arsenite(3-) increases expression ISO RGD:1551083 6480464 arsenite results in increased expression of KLF5 mRNA CTD PMID:15868481 arsenous acid decreases response to substance EXP 6480464 KLF5 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KLF5 mRNA CTD PMID:15761015 , PMID:20458559 atrazine affects methylation ISO RGD:621446 6480464 Atrazine affects the methylation of KLF5 gene CTD PMID:28931070 azathioprine increases expression EXP 6480464 Azathioprine results in increased expression of KLF5 mRNA CTD PMID:22623647 baicalein decreases expression ISO RGD:1551083 6480464 baicalein results in decreased expression of KLF5 mRNA CTD PMID:24560969 belinostat increases expression EXP 6480464 belinostat results in increased expression of KLF5 mRNA CTD PMID:26272509 belinostat multiple interactions EXP 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA CTD PMID:27188386 benzo[a]pyrene multiple interactions ISO RGD:1551083 6480464 Benzo(a)pyrene affects the reaction [AHR protein binds to KLF5 promoter] CTD PMID:19654925 benzo[a]pyrene decreases expression ISO RGD:1551083 6480464 Benzo(a)pyrene results in decreased expression of KLF5 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of KLF5 mRNA CTD PMID:20064835 more ... benzo[a]pyrene decreases expression ISO RGD:621446 6480464 Benzo(a)pyrene results in decreased expression of KLF5 mRNA CTD PMID:21839799 benzo[a]pyrene increases expression ISO RGD:1551083 6480464 Benzo(a)pyrene results in increased expression of KLF5 mRNA CTD PMID:20713471 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:19150397 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of KLF5 mRNA CTD PMID:31163220 bisphenol A multiple interactions ISO RGD:621446 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of KLF5 mRNA CTD PMID:26496021 bisphenol A affects methylation ISO RGD:1551083 6480464 bisphenol A affects the methylation of KLF5 promoter CTD PMID:27334623 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KLF5 mRNA CTD PMID:20678512 , PMID:27685785 bisphenol A increases expression ISO RGD:621446 6480464 bisphenol A results in increased expression of KLF5 mRNA CTD PMID:25181051 Bisphenol A diglycidyl ether multiple interactions ISO RGD:621446 6480464 2 more ... CTD PMID:25874449 bisphenol F multiple interactions ISO RGD:1551083 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of KLF5 mRNA CTD PMID:30951980 boric acid multiple interactions ISO RGD:1551083 6480464 boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of KLF5 mRNA] CTD PMID:28285642 cadmium dichloride affects expression ISO RGD:621446 6480464 Cadmium Chloride affects the expression of KLF5 mRNA CTD PMID:22110744 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of KLF5 mRNA CTD PMID:26472689 calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of KLF5 mRNA CTD PMID:21592394 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of KLF5 mRNA CTD PMID:21592394 , PMID:26485663 carbon nanotube decreases expression ISO RGD:1551083 6480464 Nanotubes, Carbon results in decreased expression of KLF5 mRNA CTD PMID:25554681 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of KLF5 mRNA CTD PMID:31047983 chloroprene increases expression ISO RGD:621446 6480464 Chloroprene results in increased expression of KLF5 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:1551083 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF5 mRNA CTD PMID:20938992 cobalt dichloride increases expression ISO RGD:621446 6480464 cobaltous chloride results in increased expression of KLF5 mRNA CTD PMID:24386269 cocaine affects expression ISO RGD:621446 6480464 Cocaine affects the expression of KLF5 mRNA CTD PMID:20187946 copper atom increases expression EXP 6480464 Copper results in increased expression of KLF5 mRNA CTD PMID:19747488 copper(0) increases expression EXP 6480464 Copper results in increased expression of KLF5 mRNA CTD PMID:19747488 copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of KLF5 mRNA CTD PMID:19549813 copper(II) sulfate increases expression ISO RGD:1551083 6480464 Copper Sulfate results in increased expression of KLF5 mRNA CTD PMID:18579281 cucurbitacin B increases expression ISO RGD:1551083 6480464 cucurbitacin B results in increased expression of KLF5 CTD PMID:24316209 cucurbitacin I increases expression ISO RGD:1551083 6480464 cucurbitacin I results in increased expression of KLF5 CTD PMID:24316209 cumene multiple interactions ISO RGD:1551083 6480464 [cumene co-treated with KRAS gene mutant form] results in increased expression of KLF5 mRNA CTD PMID:18648096 cyclophosphamide affects response to substance EXP 6480464 KLF5 protein affects the susceptibility to Cyclophosphamide CTD PMID:16217747 cyclosporin A increases expression ISO RGD:621446 6480464 Cyclosporine results in increased expression of KLF5 mRNA CTD PMID:21865292 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of KLF5 mRNA CTD PMID:27989131 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of KLF5 mRNA CTD PMID:20106945 , PMID:25562108 decabromodiphenyl ether increases expression ISO RGD:621446 6480464 decabromobiphenyl ether results in increased expression of KLF5 mRNA CTD PMID:23914054 decabromodiphenyl ether decreases expression ISO RGD:621446 6480464 decabromobiphenyl ether results in decreased expression of KLF5 mRNA CTD PMID:23640034 dexamethasone multiple interactions ISO RGD:1551083 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA more ... CTD PMID:16054899 more ... dexamethasone increases expression ISO RGD:1551083 6480464 Dexamethasone results in increased expression of KLF5 mRNA CTD PMID:21041162 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KLF5 mRNA CTD PMID:15761015 , PMID:20458559 diarsenic trioxide decreases response to substance EXP 6480464 KLF5 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 dibutyl phthalate increases expression ISO RGD:621446 6480464 Dibutyl Phthalate results in increased expression of KLF5 mRNA CTD PMID:21266533 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects response to substance EXP 6480464 KLF5 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of KLF5 mRNA CTD PMID:29803840 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of KLF5 mRNA CTD PMID:28940058 endosulfan increases expression ISO RGD:621446 6480464 Endosulfan results in increased expression of KLF5 mRNA CTD PMID:29391264 etoposide increases expression EXP 6480464 Etoposide results in increased expression of KLF5 mRNA CTD PMID:29397400 flavonoids decreases expression ISO RGD:621446 6480464 Flavonoids results in decreased expression of KLF5 mRNA CTD PMID:18035473 fluoranthene multiple interactions ISO RGD:1551083 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA, SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA] CTD PMID:28329830 folic acid multiple interactions ISO RGD:1551083 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF5 mRNA CTD PMID:20938992 furan increases methylation ISO RGD:621446 6480464 furan results in increased methylation of KLF5 gene CTD PMID:22079235 furan increases expression ISO RGD:621446 6480464 furan results in increased expression of KLF5 mRNA CTD PMID:27387713 geraniol increases expression EXP 6480464 geraniol results in increased expression of KLF5 mRNA CTD PMID:27683099 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of KLF5 mRNA CTD PMID:20044591 kojic acid increases expression EXP 6480464 kojic acid results in increased expression of KLF5 mRNA CTD PMID:16595896 L-methionine multiple interactions ISO RGD:1551083 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF5 mRNA CTD PMID:20938992 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of KLF5 mRNA CTD PMID:28988120 lipopolysaccharide multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with resveratrol] results in decreased expression of KLF5 mRNA CTD PMID:26667767 manganese(II) chloride decreases expression ISO RGD:1551083 6480464 manganese chloride results in decreased expression of KLF5 mRNA CTD PMID:17467022 manganese(II) chloride decreases methylation ISO RGD:621446 6480464 manganese chloride results in decreased methylation of KLF5 gene CTD PMID:28801915 manganese(II) chloride increases expression ISO RGD:621446 6480464 manganese chloride results in increased expression of KLF5 mRNA CTD PMID:28801915 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of KLF5 mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA CTD PMID:27188386 methamphetamine increases expression ISO RGD:621446 6480464 Methamphetamine results in increased expression of KLF5 mRNA CTD PMID:19564919 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of KLF5 mRNA CTD PMID:28001369 N-nitrosodimethylamine increases expression ISO RGD:621446 6480464 Dimethylnitrosamine results in increased expression of KLF5 mRNA CTD PMID:18095165 nickel dichloride affects expression ISO RGD:621446 6480464 nickel chloride affects the expression of KLF5 mRNA CTD PMID:22110744 ozone multiple interactions ISO RGD:1551083 6480464 pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA] CTD PMID:17460151 p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of KLF5 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA CTD PMID:27188386 panobinostat increases expression EXP 6480464 panobinostat results in increased expression of KLF5 mRNA CTD PMID:26272509 panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA CTD PMID:27188386 paracetamol decreases expression ISO RGD:1551083 6480464 Acetaminophen results in decreased expression of KLF5 mRNA CTD PMID:17585979 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of KLF5 mRNA CTD PMID:25458485 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of KLF5 mRNA CTD PMID:21420995 , PMID:29067470 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of KLF5 mRNA CTD PMID:25868421 perfluorooctanoic acid increases activity EXP 6480464 perfluorooctanoic acid results in increased activity of KLF5 protein CTD PMID:27589886 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of KLF5 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA CTD PMID:27188386 phosgene affects expression ISO RGD:1551083 6480464 Phosgene affects the expression of KLF5 mRNA CTD PMID:16300373 pioglitazone multiple interactions ISO RGD:621446 6480464 pioglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 mRNA], pioglitazone inhibits the reaction [AGT protein results in increased expression of KLF5 protein] CTD PMID:25874449 progesterone increases expression EXP 6480464 Progesterone results in increased expression of KLF5 mRNA CTD PMID:18037150 , PMID:18070364 Ptaquiloside decreases expression ISO RGD:1551083 6480464 ptaquiloside results in decreased expression of KLF5 mRNA CTD PMID:23274088 quercetin increases expression EXP 6480464 Quercetin results in increased expression of KLF5 mRNA CTD PMID:21632981 resveratrol multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with resveratrol] results in decreased expression of KLF5 mRNA CTD PMID:26667767 rifampicin multiple interactions EXP 6480464 [Rifampin co-treated with NR1I2 protein] results in increased expression of KLF5 mRNA CTD PMID:21127053 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of KLF5 mRNA CTD PMID:29955902 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [TGFB1 protein results in decreased expression of KLF5 mRNA] CTD PMID:21712382 SB 203580 multiple interactions ISO RGD:1551083 6480464 SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF5 mRNA] CTD PMID:28329830 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SCH 23390 decreases expression ISO RGD:621446 6480464 SCH 23390 results in decreased expression of KLF5 mRNA CTD PMID:19564919 silibinin multiple interactions ISO RGD:1551083 6480464 Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF5 mRNA] CTD PMID:25559859 silver atom increases expression EXP 6480464 Silver results in increased expression of KLF5 mRNA CTD PMID:26014281 silver(0) increases expression EXP 6480464 Silver results in increased expression of KLF5 mRNA CTD PMID:26014281 sirolimus increases expression ISO RGD:621446 6480464 Sirolimus results in increased expression of KLF5 mRNA CTD PMID:21865292 sodium arsenate increases expression ISO RGD:1551083 6480464 sodium arsenate results in increased expression of KLF5 mRNA CTD PMID:21795629 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of KLF5 mRNA CTD PMID:12760830 sodium dichromate affects expression ISO RGD:621446 6480464 sodium bichromate affects the expression of KLF5 mRNA CTD PMID:22110744 Soman increases expression ISO RGD:621446 6480464 Soman results in increased expression of KLF5 mRNA CTD PMID:19281266 sulindac increases expression EXP 6480464 Sulindac results in increased expression of KLF5 mRNA CTD PMID:11906190 tacrolimus hydrate increases expression ISO RGD:621446 6480464 Tacrolimus results in increased expression of KLF5 mRNA CTD PMID:21865292 tamibarotene multiple interactions EXP 6480464 tamibarotene inhibits the reaction [[KLF5 protein binds to [RARA protein binds to RXRA protein]] which binds to PDGFA promoter] more ... CTD PMID:16224062 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of KLF5 mRNA CTD PMID:21592394 testosterone increases expression EXP 6480464 Testosterone results in increased expression of KLF5 mRNA CTD PMID:21592394 tetrachloromethane multiple interactions ISO RGD:621446 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of KLF5 mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:621446 6480464 Carbon Tetrachloride results in increased expression of KLF5 mRNA CTD PMID:31150632 tetraphene decreases expression ISO RGD:1551083 6480464 benz(a)anthracene results in decreased expression of KLF5 mRNA CTD PMID:26377693 titanium dioxide decreases expression ISO RGD:1551083 6480464 titanium dioxide results in decreased expression of KLF5 mRNA CTD PMID:23557971 topotecan decreases expression ISO RGD:621446 6480464 Topotecan results in decreased expression of KLF5 mRNA CTD PMID:25729387 triacsin C increases expression EXP 6480464 triacsin C results in increased expression of KLF5 mRNA CTD PMID:16704987 trichostatin A multiple interactions EXP 6480464 [Decitabine co-treated with trichostatin A] results in increased expression of KLF5 mRNA more ... CTD PMID:20678512 , PMID:27188386 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of KLF5 mRNA CTD PMID:20678512 more ... undecane decreases expression ISO RGD:621446 6480464 undecane results in decreased expression of KLF5 protein CTD PMID:17337753 urethane increases expression EXP 6480464 Urethane results in increased expression of KLF5 mRNA CTD PMID:28818685 valproic acid increases expression ISO RGD:1551083 6480464 Valproic Acid results in increased expression of KLF5 mRNA CTD PMID:21427059 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF5 mRNA CTD PMID:27188386 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of KLF5 mRNA CTD PMID:23179753 more ... valproic acid decreases expression ISO RGD:1551083 6480464 Valproic Acid results in decreased expression of KLF5 mRNA CTD PMID:19136453 vinclozolin affects expression ISO RGD:621446 6480464 vinclozolin affects the expression of KLF5 mRNA CTD PMID:19015723 vinclozolin increases expression ISO RGD:621446 6480464 vinclozolin results in increased expression of KLF5 mRNA CTD PMID:23034163 , PMID:23555832
Gene-Chemical Interaction Annotations
