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Gene: THBS1 (thrombospondin 1) Homo sapiens
Symbol: THBS1
Name: thrombospondin 1
Description: Exhibits several functions, including anion binding activity; collagen V binding activity; and fibrinogen binding activity. Involved in several processes, including regulation of cell migration; regulation of protein metabolic process; and regulation of signal transduction. Localizes to several cellular components, including external side of plasma membrane; fibrinogen complex; and platelet alpha granule. Implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Biomarker of cholangiocarcinoma; obesity; pancreatic cancer; pancreatic ductal carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glycoprotein G; THBS; THBS-1; thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; TSP; TSP-1; TSP1
Mus musculus (house mouse) : Thbs1 (thrombospondin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thbs1 (thrombospondin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thbs1 (thrombospondin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : THBS1 (thrombospondin 1)
Canis lupus familiaris (dog) : THBS1 (thrombospondin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thbs1 (thrombospondin 1)
Sus scrofa (pig) : THBS1 (thrombospondin 1)
Chlorocebus sabaeus (African green monkey) : THBS1 (thrombospondin 1)
Heterocephalus glaber (naked mole-rat) : Thbs1 (thrombospondin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371539,873,280 - 39,889,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBI
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,010,501 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on THBS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345942
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-04-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.