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Gene: MCF2 (MCF.2 cell line derived transforming sequence) Homo sapiens
Symbol: MCF2
Name: MCF.2 cell line derived transforming sequence
Description: The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARHGEF21; DBL; Oncogene MCF2 (oncogene DBL); proto-oncogene DBL; proto-oncogene MCF-2
Mus musculus (house mouse) : Mcf2 (mcf.2 transforming sequence)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mcf2 (MCF.2 cell line derived transforming sequence)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcf2 (MCF.2 cell line derived transforming sequence)
Pan paniscus (bonobo/pygmy chimpanzee) : MCF2 (MCF.2 cell line derived transforming sequence)
Canis lupus familiaris (dog) : MCF2 (MCF.2 cell line derived transforming sequence)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcf2 (MCF.2 cell line derived transforming sequence)
Sus scrofa (pig) : MCF2 (MCF.2 cell line derived transforming sequence)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X139,581,768 - 139,708,279 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X138,663,930 - 138,790,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X138,491,596 - 138,618,047 (-)NCBINCBI36hg18NCBI36
Build 34X138,389,449 - 138,450,372NCBI
CeleraX139,031,369 - 139,157,817 (-)NCBI
Cytogenetic MapXq27.1NCBI
HuRefX127,931,315 - 128,057,565 (-)NCBIHuRef
CHM1_1X138,574,821 - 138,701,280 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MCF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345996
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.