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Gene: UBE2A (ubiquitin conjugating enzyme E2 A) Homo sapiens
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Symbol: UBE2A
Name: ubiquitin conjugating enzyme E2 A
Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E2 ubiquitin-conjugating enzyme A; HHR6A; HR6A; MRXS30; MRXSN; RAD6 homolog A; RAD6A; UBC2; ubiquitin carrier protein A; ubiquitin conjugating enzyme E2A; ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-protein ligase A
Orthologs:
Mus musculus (house mouse) : Ube2a (ubiquitin-conjugating enzyme E2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ube2a (ubiquitin-conjugating enzyme E2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ube2a (ubiquitin conjugating enzyme E2 A)
Pan paniscus (bonobo/pygmy chimpanzee) : UBE2A (ubiquitin conjugating enzyme E2 A)
Canis lupus familiaris (dog) : UBE2A (ubiquitin conjugating enzyme E2 A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ube2a (ubiquitin conjugating enzyme E2 A)
Sus scrofa (pig) : UBE2A (ubiquitin conjugating enzyme E2 A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,574,467 - 119,584,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X118,708,499 - 118,718,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,592,527 - 118,602,409 (+)NCBINCBI36hg18NCBI36
Build 34X118,496,179 - 118,500,259NCBI
CeleraX119,163,202 - 119,173,086 (+)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,201,952 - 108,211,764 (+)NCBIHuRef
CHM1_1X118,619,716 - 118,629,680 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on UBE2A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346006
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.