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Gene: UPF3B (UPF3B regulator of nonsense mediated mRNA decay) Homo sapiens
Symbol: UPF3B
Name: UPF3B regulator of nonsense mediated mRNA decay
Description: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HUPF3B; hUpf3p-X; mental retardation, X-linked 62; MRX62; MRXS14; nonsense mRNA reducing factor 3B; regulator of nonsense transcripts 3B; RENT3B; up-frameshift suppressor 3 homolog B; up-frameshift suppressor 3 homolog on chromosome X; UPF3 regulator of nonsense transcripts homolog B; UPF3 regulator of nonsense transcripts homolog B (yeast); UPF3B pseudogene 1; UPF3B pseudogene 2; UPF3B pseudogene 3; UPF3B, regulator of nonsense mediated mRNA decay; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3X
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X119,805,311 - 119,853,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X118,941,115 - 118,986,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,852,017 - 118,870,996 (-)NCBINCBI36hg18NCBI36
Build 34X118,749,870 - 118,768,850NCBI
CeleraX119,422,616 - 119,441,635 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX108,461,263 - 108,479,939 (-)NCBIHuRef
CHM1_1X118,879,087 - 118,898,087 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UPF3B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346078
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.