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Gene: PTK2B (protein tyrosine kinase 2 beta) Homo sapiens
Symbol: PTK2B
Name: protein tyrosine kinase 2 beta
Description: Exhibits non-membrane spanning protein tyrosine kinase activity and protein C-terminus binding activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component organization; and positive regulation of protein phosphorylation. Localizes to several cellular components, including the focal adhesion; lamellipodium; and perinuclear region of cytoplasm. Implicated in breast cancer and hypertension. Biomarker of glomerulonephritis and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CADTK; CAK beta; CAK-beta; CAKB; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; FADK 2; FADK2; FAK2; focal adhesion kinase 2; FRNK; PKB; proline-rich tyrosine kinase 2; protein kinase B; protein-tyrosine kinase 2-beta; PTK; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
Mus musculus (house mouse) : Ptk2b (PTK2 protein tyrosine kinase 2 beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptk2b (protein tyrosine kinase 2 beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2b (protein tyrosine kinase 2 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2B (protein tyrosine kinase 2 beta)
Canis lupus familiaris (dog) : PTK2B (protein tyrosine kinase 2 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2b (protein tyrosine kinase 2 beta)
Sus scrofa (pig) : PTK2B (protein tyrosine kinase 2 beta)
Chlorocebus sabaeus (African green monkey) : PTK2B (protein tyrosine kinase 2 beta)
Heterocephalus glaber (naked mole-rat) : Ptk2b (protein tyrosine kinase 2 beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl827,311,482 - 27,459,391 (+)EnsemblGRCh38hg38GRCh38
GRCh38827,311,478 - 27,459,391 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37827,168,999 - 27,316,908 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,224,916 - 27,372,820 (+)NCBINCBI36hg18NCBI36
Build 34827,238,970 - 27,372,820NCBI
Celera826,131,907 - 26,277,021 (+)NCBI
Cytogenetic Map8p21.2NCBI
HuRef825,714,123 - 25,861,970 (+)NCBIHuRef
CHM1_1827,370,923 - 27,518,777 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Cell Lines
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTK2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346204
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.