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Gene: FCGR2B (Fc fragment of IgG receptor IIb) Homo sapiens
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Symbol: FCGR2B
Name: Fc fragment of IgG receptor IIb
Description: Exhibits IgG binding activity; amyloid-beta binding activity; and low-affinity IgG receptor activity. Involved in several processes, including Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of B cell receptor signaling pathway; and regulation of dendritic spine maintenance. Localizes to integral component of plasma membrane. Implicated in autoimmune thrombocytopenic purpura; glomerulonephritis; lymphoid leukemia; malaria; and systemic lupus erythematosus. Biomarker of end stage renal disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD32; CD32B; CDw32; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma receptor IIb; Fc gamma RIIb; fc-gamma RII-b; Fc-gamma RII-c; fc-gamma-RIIb; Fc-gamma-RIIc; FCG2; FCGR2; FCGR2C; fcRII-b; FcRII-c; IGFR2; igG Fc receptor II-b; IgG Fc receptor II-c; low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c
Orthologs:
Mus musculus (house mouse) : Fcgr2b (Fc receptor, IgG, low affinity IIb)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fcgr2b (Fc fragment of IgG receptor IIb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fcgr2b (Fc fragment of IgG receptor IIb)
Pan paniscus (bonobo/pygmy chimpanzee) : FCGR2B (Fc fragment of IgG receptor IIb)
Canis lupus familiaris (dog) : LOC100856270 (low affinity immunoglobulin gamma Fc region receptor II)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fcgr2b (Fc fragment of IgG receptor IIb)
Sus scrofa (pig) : FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))
Chlorocebus sabaeus (African green monkey) : FCGR2B (Fc fragment of IgG receptor IIb)
Heterocephalus glaber (naked mole-rat) : Fcgr2b (Fc fragment of IgG receptor IIb)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1161,663,147 - 161,678,654 (+)EnsemblGRCh38hg38GRCh38
GRCh381161,647,243 - 161,678,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,632,905 - 161,648,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,899,564 - 159,914,575 (+)NCBINCBI36hg18NCBI36
Build 341158,364,610 - 158,379,618NCBI
Celera1134,746,188 - 134,751,893 (+)NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,877,468 - 132,892,993 (+)NCBIHuRef
CHM1_11163,054,757 - 163,070,270 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nomenclature History
 
More on FCGR2B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346227
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.