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Gene: SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2) Homo sapiens
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Symbol: SOS2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Description: Predicted to have DNA binding activity; guanyl-nucleotide exchange factor activity; and protein heterodimerization activity. Predicted to be involved in G protein-coupled receptor signaling pathway; positive regulation of apoptotic process; and regulation of small GTPase mediated signal transduction. Predicted to localize to the cytosol. Implicated in Noonan syndrome 9.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ25596; guanine nucleotide exchange factor; guanine nucleotide releasing factor; NS9; son of sevenless homolog 2; SOS-2
Orthologs:
Mus musculus (house mouse) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
Sus scrofa (pig) : SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1450,117,130 - 50,231,578 (-)Ensembl
GRCh381450,117,130 - 50,231,578 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371450,583,846 - 50,698,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,653,596 - 49,767,849 (-)NCBINCBI36hg18NCBI36
Build 341449,654,811 - 49,767,751NCBI
Celera1430,450,982 - 30,565,239 (-)NCBI
Cytogenetic Map14q21.3NCBI
HuRef1430,709,316 - 30,823,581 (-)NCBIHuRef
CHM1_11450,522,549 - 50,636,772 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SOS2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346295
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.