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Gene: SAT1 (spermidine/spermine N1-acetyltransferase 1) Homo sapiens
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Symbol: SAT1
Name: spermidine/spermine N1-acetyltransferase 1
Description: The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DC21; diamine acetyltransferase 1; diamine N-acetyltransferase 1; keratosis follicularis spinulosa decalvans; KFSD; KFSDX; polyamine N-acetyltransferase 1; putrescine acetyltransferase; SAT; spermidine/spermine N(1)-acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha; SSAT; SSAT-1
Orthologs:
Mus musculus (house mouse) : Sat1 (spermidine/spermine N1-acetyl transferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sat1 (spermidine/spermine N1-acetyl transferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sat1 (spermidine/spermine N1-acetyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SAT1 (spermidine/spermine N1-acetyltransferase 1)
Canis lupus familiaris (dog) : SAT1 (spermidine/spermine N1-acetyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sat1 (spermidine/spermine N1-acetyltransferase 1)
Sus scrofa (pig) : SAT1 (spermidine/spermine N1-acetyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X23,783,158 - 23,786,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X23,801,275 - 23,804,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,711,225 - 23,714,248 (+)NCBINCBI36hg18NCBI36
Build 34X23,560,960 - 23,563,982NCBI
CeleraX27,919,647 - 27,922,702 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX21,540,756 - 21,543,811 (+)NCBIHuRef
CHM1_1X23,832,183 - 23,835,248 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SAT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346323
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.