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Gene: ERN2 (endoplasmic reticulum to nucleus signaling 2) Homo sapiens
Symbol: ERN2
Name: endoplasmic reticulum to nucleus signaling 2
Description: Exhibits several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of transcription, DNA-templated; and rRNA catabolic process. Predicted to localize to the IRE1-TRAF2-ASK1 complex; INTERACTS WITH arsane; arsenic atom; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endoplasmic reticulum to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 2; ER to nucleus signalling 2; hIRE2p; inositol-requiring 1 beta; inositol-requiring protein 2; IRE1 beta; IRE1, S. cerevisiae, homolog of; ire1-beta; IRE1b; IRE2p; serine/threonine-protein kinase/endoribonuclease IRE2
Mus musculus (house mouse) : Ern2 (endoplasmic reticulum (ER) to nucleus signalling 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ern2 (endoplasmic reticulum to nucleus signaling 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ern2 (endoplasmic reticulum to nucleus signaling 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ERN2 (endoplasmic reticulum to nucleus signaling 2)
Canis lupus familiaris (dog) : ERN2 (endoplasmic reticulum to nucleus signaling 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ern2 (endoplasmic reticulum to nucleus signaling 2)
Sus scrofa (pig) : ERN2 (endoplasmic reticulum to nucleus signaling 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1623,690,310 - 23,713,226 (-)Ensembl
GRCh381623,690,310 - 23,713,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371623,701,625 - 23,724,821 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,609,126 - 23,632,322 (-)NCBINCBI36hg18NCBI36
Build 341623,609,197 - 23,632,322NCBI
Celera1622,479,794 - 22,502,990 (-)NCBI
Cytogenetic Map16p12.2NCBI
HuRef1621,791,249 - 21,814,449 (-)NCBIHuRef
CHM1_11624,713,344 - 24,736,565 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ERN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346348
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.