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Gene: GSN (gelsolin) Homo sapiens
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Symbol: GSN
Name: gelsolin
Description: Exhibits actin binding activity; calcium ion binding activity; and myosin II binding activity. Involved in several processes, including actin filament organization; positive regulation of apoptotic process; and regulation of protein complex assembly. Localizes to several cellular components, including the actin cytoskeleton; extracellular space; and sarcoplasm. Colocalizes with the nucleus. Implicated in Finnish type amyloidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: actin-depolymerizing factor; ADF; AGEL; brevin; DKFZp313L0718
Orthologs:
Mus musculus (house mouse) : Gsn (gelsolin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsn (gelsolin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsn (gelsolin)
Pan paniscus (bonobo/pygmy chimpanzee) : GSN (gelsolin)
Canis lupus familiaris (dog) : GSN (gelsolin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsn (gelsolin)
Sus scrofa (pig) : GSN (gelsolin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389121,201,483 - 121,332,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379124,030,380 - 124,095,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,070,201 - 123,134,941 (+)NCBINCBI36hg18NCBI36
Build 349121,109,960 - 121,174,674NCBI
Celera994,678,898 - 94,743,628 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,648,171 - 93,712,883 (+)NCBIHuRef
CHM1_19124,177,269 - 124,242,004 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GSN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346375
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.