Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SPHK1 (sphingosine kinase 1) Homo sapiens
Symbol: SPHK1
Name: sphingosine kinase 1
Description: Exhibits several functions, including ATP binding activity; calmodulin binding activity; and kinase activity. Involved in several processes, including positive regulation of protein modification process; regulation of macromolecule biosynthetic process; and regulation of signal transduction. Localizes to several cellular components, including the clathrin-coated pit; cytosol; and early endosome membrane. Implicated in type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetyltransferase SPHK1; SK 1; SPHK; SPK 1
Mus musculus (house mouse) : Sphk1 (sphingosine kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sphk1 (sphingosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sphk1 (sphingosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPHK1 (sphingosine kinase 1)
Canis lupus familiaris (dog) : SPHK1 (sphingosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sphk1 (sphingosine kinase 1)
Sus scrofa (pig) : SPHK1 (sphingosine kinase 1)
Chlorocebus sabaeus (African green monkey) : SPHK1 (sphingosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Sphk1 (sphingosine kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1776,376,584 - 76,387,860 (+)Ensembl
GRCh381776,383,204 - 76,387,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371774,372,742 - 74,383,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,892,297 - 71,895,536 (+)NCBINCBI36hg18NCBI36
Build 341771,892,325 - 71,895,530NCBI
Celera1770,973,067 - 70,976,318 (+)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1769,809,173 - 69,812,424 (+)NCBIHuRef
CHM1_11774,445,769 - 74,449,020 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SPHK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346404
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.