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Gene: TNK2 (tyrosine kinase non receptor 2) Homo sapiens
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Symbol: TNK2
Name: tyrosine kinase non receptor 2
Description: Exhibits several functions, including epidermal growth factor receptor binding activity; protein kinase activity; and ubiquitin protein ligase binding activity. Involved in phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of clathrin-dependent endocytosis. Localizes to several cellular components, including the Grb2-EGFR complex; clathrin-coated pit; and cytoophidium.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACK; ACK-1; ACK1; activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; FLJ44758; FLJ45547; p21cdc42Hs; tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2
Orthologs:
Mus musculus (house mouse) : Tnk2 (tyrosine kinase, non-receptor, 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnk2 (tyrosine kinase, non-receptor, 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnk2 (tyrosine kinase non receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TNK2 (tyrosine kinase non receptor 2)
Canis lupus familiaris (dog) : TNK2 (tyrosine kinase non receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnk2 (tyrosine kinase non receptor 2)
Sus scrofa (pig) : TNK2 (tyrosine kinase non receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,863,364 - 195,909,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,590,235 - 195,635,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,074,633 - 197,120,277 (-)NCBINCBI36hg18NCBI36
Build 343197,078,545 - 197,124,190NCBI
Celera3194,132,138 - 194,176,550 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3192,870,965 - 192,916,101 (-)NCBIHuRef
CHM1_13195,555,271 - 195,606,419 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TNK2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346409
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.