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Gene: KDM1A (lysine demethylase 1A) Homo sapiens
Symbol: KDM1A
Name: lysine demethylase 1A
Description: Exhibits several functions, including DNA-binding transcription factor binding activity; histone demethylase activity; and p53 binding activity. Involved in several processes, including histone lysine demethylation; negative regulation of signal transduction by p53 class mediator; and regulation of nucleobase-containing compound metabolic process. Localizes to DNA repair complex and nuclear lumen. Biomarker of alopecia areata; breast cancer; diabetic retinopathy; and hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A; amine oxidase (flavin containing) domain 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; CPRF; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; KDM1; KIAA0601; LSD1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A; RP1-184J9.1
Mus musculus (house mouse) : Kdm1a (lysine (K)-specific demethylase 1A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm1a (lysine demethylase 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm1a (lysine demethylase 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM1A (lysine demethylase 1A)
Canis lupus familiaris (dog) : KDM1A (lysine demethylase 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm1a (lysine demethylase 1A)
Sus scrofa (pig) : KDM1A (lysine demethylase 1A)
Chlorocebus sabaeus (African green monkey) : KDM1A (lysine demethylase 1A)
Heterocephalus glaber (naked mole-rat) : Kdm1a (lysine demethylase 1A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl123,019,443 - 23,083,689 (+)EnsemblGRCh38hg38GRCh38
GRCh38123,019,443 - 23,083,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,345,937 - 23,410,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,218,533 - 23,282,771 (+)NCBINCBI36hg18NCBI36
Build 34123,091,251 - 23,155,490NCBI
Celera121,668,066 - 21,732,323 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,590,111 - 21,655,045 (+)NCBIHuRef
CHM1_1123,458,660 - 23,522,895 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM1A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346422
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.