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Gene: SPCS1 (signal peptidase complex subunit 1) Homo sapiens
Symbol: SPCS1
Name: signal peptidase complex subunit 1
CRRD ID: 1346470
Description: Predicted to have ribosome binding activity. Involved in viral protein processing and virion assembly. Localizes to integral component of endoplasmic reticulum membrane; PARTICIPATES IN biotin metabolic pathway; biotinidase deficiency pathway; holocarboxylase synthetase deficiency pathway; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; bisphenol A; chloropicrin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HSPC033; microsomal signal peptidase 12 kDa subunit; signal peptidase 12kDa; signal peptidase complex 12 kDa subunit; signal peptidase complex subunit 1 homolog; SPase 12 kDa subunit; SPC1; SPC12; YJR010C-A
Mus musculus (house mouse) : Spcs1 (signal peptidase complex subunit 1 homolog (S. cerevisiae))  MGI  Alliance
Rattus norvegicus (Norway rat) : Spcs1 (signal peptidase complex subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spcs1 (signal peptidase complex subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPCS1 (signal peptidase complex subunit 1)
Canis lupus familiaris (dog) : SPCS1 (signal peptidase complex subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spcs1 (signal peptidase complex subunit 1)
Sus scrofa (pig) : SPCS1 (signal peptidase complex subunit 1)
Chlorocebus sabaeus (African green monkey) : SPCS1 (signal peptidase complex subunit 1)
Heterocephalus glaber (naked mole-rat) : Spcs1 (signal peptidase complex subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl352,704,955 - 52,711,148 (+)EnsemblGRCh38hg38GRCh38
GRCh38352,706,106 - 52,711,148 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,739,792 - 52,742,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,714,897 - 52,717,249 (+)NCBINCBI36hg18NCBI36
Build 34352,715,165 - 52,717,222NCBI
Celera352,718,568 - 52,720,909 (+)NCBI
Cytogenetic Map3p21.1NCBI
HuRef352,801,384 - 52,803,725 (+)NCBIHuRef
CHM1_1352,692,028 - 52,694,368 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPCS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346470
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.