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Gene: GPR50 (G protein-coupled receptor 50) Homo sapiens
Symbol: GPR50
Name: G protein-coupled receptor 50
Description: This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H9; Mel1c; melatonin-related receptor; MGC125342
Mus musculus (house mouse) : Gpr50 (G-protein-coupled receptor 50)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpr50 (G protein-coupled receptor 50)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpr50 (G protein-coupled receptor 50)
Pan paniscus (bonobo/pygmy chimpanzee) : GPR50 (G protein-coupled receptor 50)
Canis lupus familiaris (dog) : GPR50 (G protein-coupled receptor 50)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpr50 (G protein-coupled receptor 50)
Sus scrofa (pig) : GPR50 (G protein-coupled receptor 50)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X151,176,584 - 151,182,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X150,345,056 - 150,349,937 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X150,095,717 - 150,100,588 (+)NCBINCBI36hg18NCBI36
Build 34X150,015,692 - 150,020,505NCBI
CeleraX150,593,370 - 150,598,251 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX139,204,459 - 139,209,328 (+)NCBIHuRef
CHM1_1X150,219,098 - 150,223,979 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPR50
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346636
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.