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Gene: WNK3 (WNK lysine deficient protein kinase 3) Homo sapiens
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Symbol: WNK3
Name: WNK lysine deficient protein kinase 3
Description: This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ30437; FLJ42662; KIAA1566; PRKWNK3; protein kinase with no lysine 3; serine/threonine-protein kinase WNK3
Orthologs:
Mus musculus (house mouse) : Wnk3 (WNK lysine deficient protein kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wnk3 (WNK lysine deficient protein kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wnk3 (WNK lysine deficient protein kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : WNK3 (WNK lysine deficient protein kinase 3)
Canis lupus familiaris (dog) : WNK3 (WNK lysine deficient protein kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wnk3 (WNK lysine deficient protein kinase 3)
Sus scrofa (pig) : WNK3 (WNK lysine deficient protein kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X54,192,823 - 54,358,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X54,219,256 - 54,384,438 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X54,239,580 - 54,401,163 (-)NCBINCBI36hg18NCBI36
Build 34X54,105,875 - 54,267,459NCBI
CeleraX58,050,484 - 58,215,673 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX51,270,978 - 51,435,935 (-)NCBIHuRef
CHM1_1X54,209,950 - 54,375,102 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on WNK3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346670
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.