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Gene: TLR9 (toll like receptor 9) Homo sapiens
Symbol: TLR9
Name: toll like receptor 9
Description: Exhibits interleukin-1 receptor binding activity and siRNA binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of DNA-binding transcription factor activity; and regulation of signal transduction. Localizes to the apical plasma membrane; basolateral plasma membrane; and cytoplasm. Implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); lung disease (multiple); and systemic lupus erythematosus. Biomarker of several diseases, including alcoholic liver cirrhosis; cervix uteri carcinoma in situ; cutaneous leishmaniasis; lung disease (multiple); and nose disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD289; toll-like receptor 9
Mus musculus (house mouse) : Tlr9 (toll-like receptor 9)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr9 (toll-like receptor 9)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr9 (toll like receptor 9)
Canis lupus familiaris (dog) : TLR9 (toll like receptor 9)
Sus scrofa (pig) : TLR9 (toll like receptor 9)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38352,221,080 - 52,226,163 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,255,096 - 52,260,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,230,138 - 52,235,219 (-)NCBINCBI36hg18NCBI36
Build 34352,230,137 - 52,233,247NCBI
Celera352,234,410 - 52,239,491 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,317,258 - 52,322,341 (-)NCBIHuRef
CHM1_1352,207,624 - 52,212,707 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLR9
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346715
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.