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Gene: PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase) Homo sapiens
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Symbol: PAICS
Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Description: Exhibits identical protein binding activity. Predicted to be involved in purine nucleobase biosynthetic process and purine ribonucleoside monophosphate biosynthetic process. Localizes to the cytoplasm. Implicated in schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADE2; ADE2H1; AIR carboxylase; AIRC; DKFZp781N1372; MGC1343; MGC5024; multifunctional protein ADE2; multifunctional protein ADE2H1; PAIS; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazolesuccinocarboxamide synthase; SAICAR synthetase
Orthologs:
Related Pseudogenes: PAICSP1   PAICSP2   PAICSP3   PAICSP4   PAICSP5   PAICSP6   PAICSP7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,435,749 - 56,464,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37457,276,682 - 57,327,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,996,672 - 57,022,291 (+)NCBINCBI36hg18NCBI36
Build 34457,142,868 - 57,168,453NCBI
Celera454,808,286 - 54,833,908 (+)NCBI
Cytogenetic Map4q12NCBI
HuRef453,256,050 - 53,281,675 (+)NCBIHuRef
CHM1_1457,337,028 - 57,362,670 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PAICS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346725
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.