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Gene: PLEKHA4 (pleckstrin homology domain containing A4) Homo sapiens
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Symbol: PLEKHA4
Name: pleckstrin homology domain containing A4
Description: Exhibits phosphatidylinositol phosphate binding activity. Involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway and positive regulation of canonical Wnt signaling pathway. Localizes to extrinsic component of cytoplasmic side of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PEPP-1; PEPP1; PH domain-containing family A member 4; phosphoinositol 3-phosphate binding protein-1; phosphoinositol 3-phosphate-binding PH domain protein 1; phosphoinositol 3-phosphate-binding protein 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; pleckstrin homology domain-containing family A member 4
Orthologs:
Mus musculus (house mouse) : Plekha4 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plekha4 (pleckstrin homology domain containing A4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plekha4 (pleckstrin homology domain containing A4)
Pan paniscus (bonobo/pygmy chimpanzee) : PLEKHA4 (pleckstrin homology domain containing A4)
Canis lupus familiaris (dog) : PLEKHA4 (pleckstrin homology domain containing A4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plekha4 (pleckstrin homology domain containing A4)
Sus scrofa (pig) : PLEKHA4 (pleckstrin homology domain containing A4)
Chlorocebus sabaeus (African green monkey) : PLEKHA4 (pleckstrin homology domain containing A4)
Heterocephalus glaber (naked mole-rat) : Plekha4 (pleckstrin homology domain containing A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1948,837,097 - 48,868,617 (-)EnsemblGRCh38hg38GRCh38
GRCh381948,837,092 - 48,868,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,340,349 - 49,371,884 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,032,167 - 54,063,670 (-)NCBINCBI36hg18NCBI36
Build 341954,032,166 - 54,063,670NCBI
Celera1946,207,718 - 46,239,248 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,716,787 - 45,748,327 (-)NCBIHuRef
CHM1_11949,342,240 - 49,373,751 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PLEKHA4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346745
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.