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Gene: KCNK18 (potassium two pore domain channel subfamily K member 18) Homo sapiens
Symbol: KCNK18
Name: potassium two pore domain channel subfamily K member 18
Description: Exhibits outward rectifier potassium channel activity. Involved in cellular response to pH and potassium ion export across plasma membrane. Localizes to plasma membrane. Implicated in migraine with aura.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: K2p18.1; MGR13; potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; TRESK; TRESK-2; TRESK2; TRIK; TWIK related spinal cord K+ channel; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel; TWIK-related spinal cord potassium channel
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10117,197,489 - 117,210,299 (+)EnsemblGRCh38hg38GRCh38
GRCh3810117,197,489 - 117,210,299 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710118,957,000 - 118,969,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,946,990 - 118,959,800 (+)NCBINCBI36hg18NCBI36
Build 3410118,946,989 - 118,959,800NCBI
Celera10112,687,102 - 112,699,920 (+)NCBI
Cytogenetic Map10q25.3NCBI
HuRef10112,584,507 - 112,597,305 (+)NCBIHuRef
CHM1_110119,241,229 - 119,254,016 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNK18
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346775
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.