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Gene: SESN2 (sestrin 2) Homo sapiens
Symbol: SESN2
Name: sestrin 2
Description: Exhibits leucine binding activity; oxidoreductase activity, acting on peroxide as acceptor; and sulfiredoxin activity. Involved in several processes, including cellular response to starvation; positive regulation of cellular metabolic process; and regulation of cellular protein metabolic process. Localizes to the cytoplasm. Colocalizes with the Atg1/ULK1 kinase complex and GATOR2 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp761M0212; DKFZp761M02121; HI95; hypoxia induced gene 95; hypoxia-induced; SES2; SEST2; sestrin-2
Mus musculus (house mouse) : Sesn2 (sestrin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sesn2 (sestrin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sesn2 (sestrin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SESN2 (sestrin 2)
Canis lupus familiaris (dog) : SESN2 (sestrin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sesn2 (sestrin 2)
Sus scrofa (pig) : SESN2 (sestrin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl128,259,518 - 28,282,491 (+)Ensembl
GRCh38128,259,452 - 28,282,491 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37128,585,963 - 28,609,002 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,458,593 - 28,481,589 (+)NCBINCBI36hg18NCBI36
Build 34128,270,147 - 28,293,143NCBI
Celera126,981,763 - 27,004,758 (+)NCBI
Cytogenetic Map1p35.3NCBI
HuRef126,842,331 - 26,865,372 (+)NCBIHuRef
CHM1_1128,701,469 - 28,724,501 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SESN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346813
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.