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Gene: SLC4A8 (solute carrier family 4 member 8) Homo sapiens
Symbol: SLC4A8
Name: solute carrier family 4 member 8
Description: The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp761B2318; electroneutral Na(+)-driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1; FLJ46462; k-NBC3; Na+-driven Cl-HCO3 exchanger; NBC3; NDCBE; solute carrier family 4, sodium bicarbonate cotransporter, member 8
Mus musculus (house mouse) : Slc4a8 (solute carrier family 4 (anion exchanger), member 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc4a8 (solute carrier family 4 member 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc4a8 (solute carrier family 4 member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC4A8 (solute carrier family 4 member 8)
Canis lupus familiaris (dog) : SLC4A8 (solute carrier family 4 member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc4a8 (solute carrier family 4 member 8)
Sus scrofa (pig) : SLC4A8 (solute carrier family 4 member 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381251,391,317 - 51,515,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371251,785,101 - 51,909,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,104,861 - 50,189,247 (+)NCBINCBI36hg18NCBI36
Build 341250,105,023 - 50,177,915NCBI
Celera1250,620,062 - 50,705,110 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1248,818,058 - 48,942,408 (+)NCBIHuRef
CHM1_11251,751,635 - 51,876,068 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC4A8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346907
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.