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Gene: NKX6-1 (NK6 homeobox 1) Homo sapiens
Symbol: NKX6-1
Name: NK6 homeobox 1
CRRD ID: 1346979
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including detection of glucose; positive regulation of type B pancreatic cell development; and regulation of transcription, DNA-templated. Localizes to extracellular exosome.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein NK-6 homolog A; homeobox protein Nkx-6.1; NK homeo box, family 6, member A; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1; NKX6.1; NKX6A
Mus musculus (house mouse) : Nkx6-1 (NK6 homeobox 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx6-1 (NK6 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx6-1 (NK6 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX6-1 (NK6 homeobox 1)
Canis lupus familiaris (dog) : NKX6-1 (NK6 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx6-1 (NK6 homeobox 1)
Sus scrofa (pig) : NKX6-1 (NK6 homeobox 1)
Chlorocebus sabaeus (African green monkey) : NKX6-1 (NK6 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Nkx6-1 (NK6 homeobox 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl484,491,987 - 84,498,450 (-)EnsemblGRCh38hg38GRCh38
GRCh38484,491,985 - 84,499,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37485,414,436 - 85,419,387 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36485,633,460 - 85,638,411 (-)NCBINCBI36hg18NCBI36
Build 34485,771,614 - 85,776,566NCBI
Celera482,704,620 - 82,709,571 (-)NCBI
Cytogenetic Map4q21.23NCBI
HuRef481,156,194 - 81,161,143 (-)NCBIHuRef
CHM1_1485,391,105 - 85,396,056 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKX6-1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1346979
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.