Gene: MYH2 (myosin heavy chain 2) Homo sapiens
Symbol: MYH2
Name: myosin heavy chain 2
Description: Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: fast 2a myosin heavy chain; IBM3; inclusion body myopathy 3, autosomal dominant; MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2; myosin heavy chain 2a; myosin heavy chain IIa; myosin heavy chain, skeletal muscle, adult 2; myosin, heavy chain 2, skeletal muscle, adult; myosin, heavy polypeptide 2, skeletal muscle, adult; myosin-2; MYPOP; type IIA myosin heavy chain
Mus musculus (house mouse) : Myh2 (myosin, heavy polypeptide 2, skeletal muscle, adult)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myh2 (myosin heavy chain 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myh2 (myosin heavy chain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MYH2 (myosin heavy chain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101958875 (myosin-2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381710,521,148 - 10,549,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371710,424,465 - 10,453,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361710,365,190 - 10,393,742 (-)NCBINCBI36hg18NCBI36
Build 341710,365,193 - 10,393,700NCBI
Celera1710,455,328 - 10,483,875 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef1710,324,058 - 10,352,633 (-)NCBIHuRef
CHM1_11710,434,312 - 10,462,875 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MYH2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347033
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-04-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.