Gene: MYH2 (myosin heavy chain 2) Homo sapiens
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Symbol: MYH2
Name: myosin heavy chain 2
Description: Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: fast 2a myosin heavy chain; IBM3; inclusion body myopathy 3, autosomal dominant; MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2; myosin heavy chain 2a; myosin heavy chain IIa; myosin heavy chain, skeletal muscle, adult 2; myosin, heavy chain 2, skeletal muscle, adult; myosin, heavy polypeptide 2, skeletal muscle, adult; myosin-2; MYPOP; type IIA myosin heavy chain
Orthologs:
Mus musculus (house mouse) : Myh2 (myosin, heavy polypeptide 2, skeletal muscle, adult)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myh2 (myosin heavy chain 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myh2 (myosin heavy chain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MYH2 (myosin heavy chain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101958875 (myosin-2)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381710,521,148 - 10,549,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371710,424,465 - 10,453,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361710,365,190 - 10,393,742 (-)NCBINCBI36hg18NCBI36
Build 341710,365,193 - 10,393,700NCBI
Celera1710,455,328 - 10,483,875 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef1710,324,058 - 10,352,633 (-)NCBIHuRef
CHM1_11710,434,312 - 10,462,875 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MYH2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347033
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-04-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.