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Gene: PCA3 (prostate cancer associated 3) Homo sapiens
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Symbol: PCA3
Name: prostate cancer associated 3
Description: This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Type: ncrna
RefSeq Status: REVIEWED
Also known as: DD3; NCRNA00019; PCAT3; prostate cancer associated 3 (non-protein coding); PRUNE2-AS1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38976,764,436 - 76,787,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37979,379,354 - 79,402,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36979,379,354 - 79,402,465 (+)NCBINCBI36hg18NCBI36
Build 34976,608,905 - 76,632,039NCBI
Celera949,954,199 - 49,977,305 (+)NCBI
Cytogenetic Map9q21.2NCBI
HuRef949,208,910 - 49,232,028 (+)NCBIHuRef
CHM1_1979,525,809 - 79,548,942 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - uncurated

Genomics

Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PCA3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347053
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.