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Gene: AKR1C4 (aldo-keto reductase family 1 member C4) Homo sapiens
Symbol: AKR1C4
Name: aldo-keto reductase family 1 member C4
CRRD ID: 1347108
Description: Exhibits androsterone dehydrogenase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and retinal dehydrogenase activity. Involved in cellular response to jasmonic acid stimulus; daunorubicin metabolic process; and doxorubicin metabolic process. Localizes to extracellular exosome. Implicated in 46,XY sex reversal 8.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4; 3-alpha hydroxysteroid dehydrogenase, type I; 3-alpha-HSD; 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; aldo-keto reductase family 1, member C4; C11; CDR; CHDR; chlordecone reductase; DD-4; DD4; dihydrodiol dehydrogenase 4; dihydrodiol dehydrogenase isozyme DD4; HAKRA; MGC22581; type I 3-alpha-hydroxysteroid dehydrogenase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl105,195,462 - 5,218,949 (+)EnsemblGRCh38hg38GRCh38
GRCh38105,196,837 - 5,218,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37105,238,798 - 5,260,910 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,228,798 - 5,250,912 (+)NCBINCBI36hg18NCBI36
Build 34105,228,797 - 5,250,912NCBI
Celera105,179,002 - 5,201,106 (+)NCBI
Cytogenetic Map10p15.1NCBI
HuRef105,173,878 - 5,196,042 (+)NCBIHuRef
CHM1_1105,239,346 - 5,261,331 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKR1C4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347108
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.