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Gene: ACE2 (angiotensin I converting enzyme 2) Homo sapiens
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Symbol: ACE2
Name: angiotensin I converting enzyme 2
Description: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACE-related carboxypeptidase; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; DKFZp434A014; metalloprotease MPROT15; peptidyl-dipeptidase A
Orthologs:
Mus musculus (house mouse) : Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ace2 (angiotensin I converting enzyme 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ace2 (angiotensin I converting enzyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACE2 (angiotensin I converting enzyme 2)
Canis lupus familiaris (dog) : ACE2 (angiotensin I converting enzyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ace2 (angiotensin I converting enzyme 2)
Sus scrofa (pig) : ACE2 (angiotensin I converting enzyme 2)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SHRSP-Tg(Tagln-ACE2)6918Bdr  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,494,520 - 15,602,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,579,156 - 15,620,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ACE2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347174
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.