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Gene: TSPAN6 (tetraspanin 6) Homo sapiens
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Symbol: TSPAN6
Name: tetraspanin 6
Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A15 homolog; putative NF-kappa-B-activating protein 321; T245; tetraspan TM4SF; tetraspanin TM4-D; tetraspanin-6; TM4SF6; transmembrane 4 superfamily member 6; TSPAN-6
Orthologs:
Mus musculus (house mouse) : Tspan6 (tetraspanin 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tspan6 (tetraspanin 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tspan6 (tetraspanin 6)
Pan paniscus (bonobo/pygmy chimpanzee) : TSPAN6 (tetraspanin 6)
Canis lupus familiaris (dog) : TSPAN6 (tetraspanin 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tspan6 (tetraspanin 6)
Sus scrofa (pig) : TSPAN6 (tetraspanin 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X100,627,108 - 100,637,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X99,882,105 - 99,892,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,770,451 - 99,778,450 (-)NCBINCBI36hg18NCBI36
Build 34X99,689,939 - 99,697,939NCBI
CeleraX100,402,531 - 100,410,530 (-)NCBI
Cytogenetic MapXq22.1NCBI
HuRefX89,659,381 - 89,692,021 (-)NCBIHuRef
CHM1_1X99,774,986 - 99,784,982 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TSPAN6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347181
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.