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Gene: TSPAN6 (tetraspanin 6) Homo sapiens
Symbol: TSPAN6
Name: tetraspanin 6
Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A15 homolog; putative NF-kappa-B-activating protein 321; T245; tetraspan TM4SF; tetraspanin TM4-D; tetraspanin-6; TM4SF6; transmembrane 4 superfamily member 6; TSPAN-6
Mus musculus (house mouse) : Tspan6 (tetraspanin 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tspan6 (tetraspanin 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tspan6 (tetraspanin 6)
Pan paniscus (bonobo/pygmy chimpanzee) : TSPAN6 (tetraspanin 6)
Canis lupus familiaris (dog) : TSPAN6 (tetraspanin 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tspan6 (tetraspanin 6)
Sus scrofa (pig) : TSPAN6 (tetraspanin 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X100,627,108 - 100,637,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X99,882,105 - 99,892,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,770,451 - 99,778,450 (-)NCBINCBI36hg18NCBI36
Build 34X99,689,939 - 99,697,939NCBI
CeleraX100,402,531 - 100,410,530 (-)NCBI
Cytogenetic MapXq22.1NCBI
HuRefX89,659,381 - 89,692,021 (-)NCBIHuRef
CHM1_1X99,774,986 - 99,784,982 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TSPAN6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347181
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.