Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IGL (immunoglobulin lambda locus) Homo sapiens
Analyze
Symbol: IGL
Name: immunoglobulin lambda locus
Description: Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ig lambda-6 chain C region; IGL@; IGLC6; immunoglobulin lambda gene cluster; MGC88804
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,026,076 - 22,922,913 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,380,474 - 23,265,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,710,659 - 21,595,085 (+)NCBINCBI36hg18NCBI36
Celera226,197,990 - 7,079,666 (+)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,337,286 - 6,232,859 (+)NCBIHuRef
CHM1_12222,380,546 - 23,277,383 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Position Markers

Expression


Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IGL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347208
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.