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Gene: BIRC2 (baculoviral IAP repeat containing 2) Homo sapiens
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Symbol: BIRC2
Name: baculoviral IAP repeat containing 2
CRRD ID: 1347209
Description: Exhibits several functions, including FBXO family protein binding activity; chaperone binding activity; and transcription coactivator activity. Involved in several processes, including cellular protein metabolic process; positive regulation of protein ubiquitination; and regulation of programmed cell death. Localizes to cytoplasm and nucleus. Implicated in breast cancer. Biomarker of cervical cancer; cervical squamous cell carcinoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: API1; apoptosis inhibitor 1; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 2; c-IAP1; cellular inhibitor of apoptosis 1; cIAP1; Hiap-2; HIAP2; IAP homolog B; IAP-2; inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
Orthologs:
Mus musculus (house mouse) : Birc2 (baculoviral IAP repeat-containing 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Birc2 (baculoviral IAP repeat-containing 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Birc2 (baculoviral IAP repeat containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BIRC2 (baculoviral IAP repeat containing 2)
Canis lupus familiaris (dog) : BIRC2 (baculoviral IAP repeat containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Birc2 (baculoviral IAP repeat containing 2)
Chlorocebus sabaeus (African green monkey) : BIRC2 (baculoviral IAP repeat containing 2)
Heterocephalus glaber (naked mole-rat) : Birc2 (baculoviral IAP repeat containing 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11102,347,211 - 102,378,670 (+)EnsemblGRCh38hg38GRCh38
GRCh3811102,347,182 - 102,378,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,217,913 - 102,249,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,723,176 - 101,754,611 (+)NCBINCBI36hg18NCBI36
Build 3411101,723,175 - 101,754,610NCBI
Celera1199,379,519 - 99,410,957 (+)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBIHuRef
CHM1_111102,100,910 - 102,132,418 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BIRC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347209
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.