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Gene: CD14 (CD14 molecule) Homo sapiens
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Symbol: CD14
Name: CD14 molecule
Description: Exhibits lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in cellular response to molecule of bacterial origin; positive regulation of NIK/NF-kappaB signaling; and positive regulation of cytokine production. Localizes to several cellular components, including the anchored component of external side of plasma membrane; lipopolysaccharide receptor complex; and membrane raft. Implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Biomarker of several diseases, including biliary atresia; cystic fibrosis; lung disease (multiple); perinatal necrotizing enterocolitis; and polycystic kidney disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cd14 antigen; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
Orthologs:
Mus musculus (house mouse) : Cd14 (CD14 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd14 (CD14 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd14 (CD14 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD14 (CD14 molecule)
Canis lupus familiaris (dog) : CD14 (CD14 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd14 (CD14 molecule)
Sus scrofa (pig) : CD14 (CD14 molecule)
Chlorocebus sabaeus (green monkey) : CD14 (CD14 molecule)
Heterocephalus glaber (naked mole-rat) : Cd14 (CD14 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5140,631,728 - 140,633,701 (-)Ensembl
GRCh385140,631,728 - 140,633,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375140,011,313 - 140,013,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,991,501 - 139,993,439 (-)NCBINCBI36hg18NCBI36
Build 345139,991,504 - 139,992,956NCBI
Celera5136,088,058 - 136,090,031 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5135,156,588 - 135,158,561 (-)NCBIHuRef
CHM1_15139,444,555 - 139,446,528 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CD14
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347263
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.