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Gene: SKP1 (S-phase kinase associated protein 1) Homo sapiens
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Symbol: SKP1
Name: S-phase kinase associated protein 1
Description: Exhibits several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin protein ligase activity; and protein ubiquitination. Localizes to cullin-RING ubiquitin ligase complex; cytoplasm; and nucleus. Colocalizes with PcG protein complex.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated protein p19; EMC19; MGC34403; OCP-2; OCP-II; OCP2; organ of Corti protein 2; organ of Corti protein II; p19A; p19skp1; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; SIII; SKP1A; TCEB1L; transcription elongation factor B; transcription elongation factor B (SIII), polypeptide 1-like; transcription elongation factor B polypeptide 1-like
Orthologs:
Mus musculus (house mouse) : Skp1 (S-phase kinase-associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Skp1 (S-phase kinase-associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Skp1 (S-phase kinase associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SKP1 (S-phase kinase associated protein 1)
Canis lupus familiaris (dog) : SKP1 (S-phase kinase associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Skp1 (S-phase kinase associated protein 1)
Sus scrofa (pig) : SKP1 (S-phase kinase associated protein 1)
Chlorocebus sabaeus (African green monkey) : SKP1 (S-phase kinase associated protein 1)
Heterocephalus glaber (naked mole-rat) : Skp1 (S-phase kinase associated protein 1)
more info ...
Related Pseudogenes: SKP1P1   SKP1P2   SKP1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5134,148,935 - 134,177,038 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5134,148,935 - 134,176,964 (-)EnsemblGRCh38hg38GRCh38
GRCh385134,148,935 - 134,177,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375133,492,082 - 133,512,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,520,468 - 133,540,583 (-)NCBINCBI36hg18NCBI36
Build 345133,520,467 - 133,540,583NCBI
Celera5129,615,775 - 129,636,409 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5128,677,052 - 128,697,683 (-)NCBIHuRef
CHM1_15132,924,656 - 132,945,272 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SKP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347276
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.