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Gene: SMAD2 (SMAD family member 2) Homo sapiens
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Symbol: SMAD2
Name: SMAD family member 2
Description: Exhibits several functions, including SMAD binding activity; enzyme binding activity; and nucleic acid binding activity. Contributes to DNA binding activity. Involved in several processes, including regulation of transcription, DNA-templated; transmembrane receptor protein serine/threonine kinase signaling pathway; and zygotic specification of dorsal/ventral axis. Localizes to the RNA polymerase II transcription factor complex; cytoplasm; and nuclear chromatin. Implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Biomarker of breast carcinoma; endocrine gland cancer (multiple); endometrial cancer; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; Mad protein homolog; MAD, mothers against decapentaplegic homolog 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD, mothers against DPP homolog 2; smad, mothers against dpp homolog 2 (drosophila)
Orthologs:
Mus musculus (house mouse) : Smad2 (SMAD family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smad2 (SMAD family member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad2 (SMAD family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD2 (SMAD family member 2)
Canis lupus familiaris (dog) : SMAD2 (SMAD family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad2 (SMAD family member 2)
Sus scrofa (pig) : SMAD2 (SMAD family member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381847,808,957 - 47,931,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371845,359,466 - 45,457,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,613,464 - 43,711,510 (-)NCBINCBI36hg18NCBI36
Build 341843,618,434 - 43,710,924NCBI
Celera1842,208,816 - 42,306,655 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1842,208,822 - 42,306,925 (-)NCBIHuRef
CHM1_11845,354,416 - 45,452,506 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SMAD2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347299
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.