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Gene: SMAD2 (SMAD family member 2) Homo sapiens
Symbol: SMAD2
Name: SMAD family member 2
Description: Exhibits several functions, including SMAD binding activity; enzyme binding activity; and nucleic acid binding activity. Contributes to DNA binding activity. Involved in several processes, including regulation of transcription, DNA-templated; transmembrane receptor protein serine/threonine kinase signaling pathway; and zygotic specification of dorsal/ventral axis. Localizes to the RNA polymerase II transcription factor complex; cytoplasm; and nuclear chromatin. Implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Biomarker of breast carcinoma; endocrine gland cancer (multiple); endometrial cancer; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; Mad protein homolog; MAD, mothers against decapentaplegic homolog 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD, mothers against DPP homolog 2; smad, mothers against dpp homolog 2 (drosophila)
Mus musculus (house mouse) : Smad2 (SMAD family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smad2 (SMAD family member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad2 (SMAD family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD2 (SMAD family member 2)
Canis lupus familiaris (dog) : SMAD2 (SMAD family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad2 (SMAD family member 2)
Sus scrofa (pig) : SMAD2 (SMAD family member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381847,808,957 - 47,931,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371845,359,466 - 45,457,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,613,464 - 43,711,510 (-)NCBINCBI36hg18NCBI36
Build 341843,618,434 - 43,710,924NCBI
Celera1842,208,816 - 42,306,655 (-)NCBI
Cytogenetic Map18q21.1NCBI
HuRef1842,208,822 - 42,306,925 (-)NCBIHuRef
CHM1_11845,354,416 - 45,452,506 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMAD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347299
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.