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Gene: TSIX (TSIX transcript, XIST antisense RNA) Homo sapiens
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Symbol: TSIX
Name: TSIX transcript, XIST antisense RNA
Description: In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]
Type: ncrna
RefSeq Status: REVIEWED
Also known as: LINC00013; NCRNA00013; XIST-AS; XIST-AS1; XISTAS
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X73,792,205 - 73,829,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X73,012,040 - 73,049,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X73,012,040 - 73,049,066 (+)NCBINCBI36hg18NCBI36
CeleraX73,295,516 - 73,332,546 (+)NCBI
Cytogenetic MapXq13.2NCBI
HuRefX66,646,182 - 66,683,292 (+)NCBIHuRef
CHM1_1X72,904,822 - 72,941,845 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TSIX
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1347301
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.